PAÜ .:. Eğitim Öğretim Bilgi Sistemi

COURSE INFORMATION

Course Code	Course Title	L+P Hour	Semester	ECTS
TBI 603	EPIGENETICS	2 + 0	3rd Semester	5

COURSE DESCRIPTION

Course Level	Doctorate Degree
Course Type	Elective
Course Objective	To understand the basic molecular mechanisms of epigenetic processes include DNA methylation, histone modifications, genomic imprinting, non-coding RNAs during development, differentiation, carcinogenesis, and reprogramming, To discuss how gene regulatory information that is not expressed in the DNA sequence is transmitted from one generation to the next, To discuss how epigenetic mechanisms act in cell division and differentiation, and how errors in these pathways contribute to cancer and other human diseases. .
Course Content	Epigenetic mechanisms in gene regulation DNA methylation and cancer; therapeutic opportunities DNA methylation and recurrent chromosome instability DNA methylation and viral gene expression Genomic imprinting, abnormal genomic imprinting and related diseases Methods in epigenetics Role of DNA methylation in development, epigenetic mechanisms in diffrentiation of embriyonic stem cells, cell differentiation, and preservation of pluripotent cells during development. .
Prerequisites	No the prerequisite of lesson.
Corequisite	No the corequisite of lesson.
Mode of Delivery	Face to Face

COURSE LEARNING OUTCOMES

1	Explains the epigenetic mechanisms at the molecular level.
2	Explains the role of epigenetic mechanisms in the maintenance of homeostasis.
3	Defines and discusses how the loss of epigenetic control causes human diseases
4	Reveals therapeutic approaches in epigenetic defects.

COURSE'S CONTRIBUTION TO PROGRAM

	PO 01	PO 02	PO 03	PO 04	PO 05	PO 06	PO 07	PO 08	PO 09	PO 10	PO 11	PO 12
LO 001	4	1	4	2		3	1	3		2	2
LO 002	4	1	4	2		3	1	3		2	2
LO 003	4	1	4	2		3	1	3		2	2
LO 004	2		2			1		2
Sub Total	14	3	14	6		10	3	11		6	6
Contribution	4	1	4	2	0	3	1	3	0	2	2	0

ECTS ALLOCATED BASED ON STUDENT WORKLOAD BY THE COURSE DESCRIPTION

Activities	Quantity	Duration (Hour)	Total Work Load (Hour)
Course Duration (14 weeks/theoric+practical)	14	2	28
Hours for off-the-classroom study (Pre-study, practice)	14	2	28
Mid-terms	1	30	30
Final examination	1	44	44
Total Work Load ECTS Credit of the Course			130 5

COURSE DETAILS

Select Year

Course Details

Course Code	Course Title	L+P Hour	Course Code	Language Of Instruction	Course Semester
TBI 603	EPIGENETICS	2 + 0	1	Turkish	2023-2024 Fall

Course Coordinator	E-Mail	Phone Number	Course Location	Attendance
Assoc. Prof. Dr. SELDA ŞİMŞEK	seldas@pau.edu.tr		KKM A0306	%90

Goals		To understand the basic molecular mechanisms of epigenetic processes include DNA methylation, histone modifications, genomic imprinting, non-coding RNAs during development, differentiation, carcinogenesis, and reprogramming, To discuss how gene regulatory information that is not expressed in the DNA sequence is transmitted from one generation to the next, To discuss how epigenetic mechanisms act in cell division and differentiation, and how errors in these pathways contribute to cancer and other human diseases. .
Content		Epigenetic mechanisms in gene regulation DNA methylation and cancer; therapeutic opportunities DNA methylation and recurrent chromosome instability DNA methylation and viral gene expression Genomic imprinting, abnormal genomic imprinting and related diseases Methods in epigenetics Role of DNA methylation in development, epigenetic mechanisms in diffrentiation of embriyonic stem cells, cell differentiation, and preservation of pluripotent cells during development. .

Topics

Weeks	Topics
1	Introduction to Epigenetic Mechanisms of Gene Regulation
2	DNA methylation and the target regions in human genome for DNA methylation
3	Histone modifications, histone code and mechanisms of chromatin remodelling
4	Non-coding RNAs: Main functions
5	Genomic imprinting
6	Methods of Epigenetic Analysis
7	DNA methylation and carcinogenesis
8	Literature discussion
9	DNA methylation and Repeat Instability Diseases
10	epigenetic mechanisms in the regulation of differentiation and the maintanence of pluripotency
11	Roles of histone modifications and chromatin remodelling in carcinogenesis
12	Roles of non-coding RNAs in carcinogenesis
13	Literature discussion
14	Diseases Associated with Abnormal Imprinting and loss of imprinting in cancer

Materials

Materials are not specified.

Resources

Resources	Resources Language
Epigenetics, Allis CD et al., 1st edition, Cold Spring Harbor Laboratory Press, 2006.	English

Course Assessment

Assesment Methods	Percentage (%)	Assesment Methods Title
Final Exam	50	Final Exam
Midterm Exam	50	Midterm Exam

L+P: Lecture and Practice
PQ: Program Learning Outcomes
LO: Course Learning Outcomes

Prospective Student