PAÜ .:. Eğitim Öğretim Bilgi Sistemi

COURSE INFORMATION

Course Code	Course Title	L+P Hour	Semester	ECTS
BIO 541	PROTEIN STRUCTURE-FUNCTION RELATIONSHIPS	3 + 0	1st Semester	7,5

COURSE DESCRIPTION

Course Level	Master's Degree
Course Type	Elective
Course Objective	Give basic knowledge about recent advances in protein structure-function relationships from both a biological and chemical perspective.
Course Content	Primary & Secondary Structure of proteins, Motifs & Supersecondary Structure, Tertiary Structure & Fold Types, Forces that Determine Protein Structure, Mechanisms of Protein Folding Pathways, Background and Basic Principles, Absorption and Fluorescence, Circular Dichroism and Optical Rotation, Fluctuation Spectroscopy, Mass Spectrometry, X-Ray Crystallography, Basic NMR Principles and Parameters, 19F NMR Studies of Protein Folding, Protein Structure Determination, Ligand-Protein Interactions .
Prerequisites	No the prerequisite of lesson.
Corequisite	No the corequisite of lesson.
Mode of Delivery	Face to Face

COURSE LEARNING OUTCOMES

1	Will be able to know Primary and Secondary Structure, Motifs & Supersecondary Structure of proteins
2	Will be able to know Forces that Determine Protein Structure
3	Will be able to know Mechanisms of Protein Folding Pathways
4	Will be able to know Protein Sorting
5	Will be able to know the techniques used in Protein analysis
6	Will be able to know Protein Structure Determination
7	Will be able to know Ligand-Protein Interactions

COURSE'S CONTRIBUTION TO PROGRAM

	PO 01	PO 02	PO 03	PO 04	PO 05	PO 06	PO 07	PO 08	PO 09	PO 10	PO 11
LO 001	4	3	3	3	5			3	5
LO 002	5	2	2	4	5			4	5
LO 003	5	4	3	3	5			3	5
LO 004	4	4	4	3	5			5	5
LO 005	5	5	2	3	5			4	4
LO 006	5	4	3	3	5			3	4
LO 007	5	3	4	4	5			2	4
Sub Total	33	25	21	23	35			24	32
Contribution	5	4	3	3	5	0	0	3	5	0	0

ECTS ALLOCATED BASED ON STUDENT WORKLOAD BY THE COURSE DESCRIPTION

Activities	Quantity	Duration (Hour)	Total Work Load (Hour)
Course Duration (14 weeks/theoric+practical)	14	3	42
Hours for off-the-classroom study (Pre-study, practice)	14	7	98
Assignments	1	5	5
Mid-terms	1	15	15
Final examination	1	35	35
Total Work Load ECTS Credit of the Course			195 7,5

COURSE DETAILS

Select Year

	Course Term	No	Instructors
Details	2013-2014 Fall	1	ALAATTİN ŞEN

Course Details

Course Code	Course Title	L+P Hour	Course Code	Language Of Instruction	Course Semester
BIO 541	PROTEIN STRUCTURE-FUNCTION RELATIONSHIPS	3 + 0	1	Turkish	2013-2014 Fall

Course Coordinator	E-Mail	Phone Number	Course Location	Attendance
Prof. Dr. ALAATTİN ŞEN	sena@pau.edu.tr		FEN B0112	%85

Goals		Give basic knowledge about recent advances in protein structure-function relationships from both a biological and chemical perspective.
Content		Primary & Secondary Structure of proteins, Motifs & Supersecondary Structure, Tertiary Structure & Fold Types, Forces that Determine Protein Structure, Mechanisms of Protein Folding Pathways, Background and Basic Principles, Absorption and Fluorescence, Circular Dichroism and Optical Rotation, Fluctuation Spectroscopy, Mass Spectrometry, X-Ray Crystallography, Basic NMR Principles and Parameters, 19F NMR Studies of Protein Folding, Protein Structure Determination, Ligand-Protein Interactions .

Topics

Weeks	Topics
1	What is Proteomics?
2	Introduction to Protein Structure
3	Determining Protein Structure
4	Structure and Function Relationships of Proteins
5	Protein Modification
6	Genomics-Based Predictions of Cellular Proteins
7	2D Gel Electrophoresis to Identify Cellular Proteins
8	Mass Spectrometry to Identify Cellular Proteins
9	Identifying Protein Interactions
10	The Yeast Two-Hybrid System
11	Protein Microarrays
12	Protein Networks
13	Proteomes in Different Organisms
14	Proteomics and Drug Discovery

Materials

Materials are not specified.

Resources

Course Assessment

Assesment Methods	Percentage (%)	Assesment Methods Title
Final Exam	50	Final Exam
Midterm Exam	50	Midterm Exam

L+P: Lecture and Practice
PQ: Program Learning Outcomes
LO: Course Learning Outcomes

Prospective Student