PAÜ .:. Eğitim Öğretim Bilgi Sistemi

COURSE INFORMATION

Course Code	Course Title	L+P Hour	Semester	ECTS
BIO 589	MONOOXYGENASES	3 + 0	2nd Semester	7,5

COURSE DESCRIPTION

Course Level	Master's Degree
Course Type	Elective
Course Objective	Examine the role of moonoxgenases in normal metabolic pathways and xenobiotics metabolism in detail along with the current publications.
Course Content	Fundamental concepts on oxidases and oxygenases. Mechanism of action of monooxygenases. Special emphasis will be given on human enzymes including cytochrome P450- and cytochrome b5-dependent monooxygenases, flavin containing monooxygenases and nitric oxide synthase. Their importance in health and disease. Their structure, active sites, endogenous and exogenous substrates, structure-activity relationships, membrane topology, isomeric forms, molecular biology, gene structures and control mechanisms. Functions in human biochemistry including cholesterol, steroid hormone and vitamin synthesis and degradation, in drug metabolism and chemical carcinogenesis. The course includes lectures and discussions of recent journal articles.
Prerequisites	No the prerequisite of lesson.
Corequisite	No the corequisite of lesson.
Mode of Delivery	Face to Face

COURSE LEARNING OUTCOMES

1	Will be able to know oxygenases
2	Will be able to know cytochrome P450s
3	Will be able to know Flavine containing monoxygenases
4	Will be able to know their role in steroid metabolism
5	Will be able to know their role in drug metabolis
6	Will be able to know their role in carcinogenesis

COURSE'S CONTRIBUTION TO PROGRAM

	PO 01	PO 02	PO 03	PO 04	PO 05	PO 06	PO 07	PO 08	PO 09	PO 10	PO 11
LO 001	4	5	4		5	4	4	4
LO 002		3		4		3	3	4	3	5
LO 003	4	4		4
LO 004			4	4
LO 005	4		5	4
LO 006	4	5	4	5
Sub Total	16	17	17	21	5	7	7	8	3	5
Contribution	3	3	3	4	1	1	1	1	1	1	0

ECTS ALLOCATED BASED ON STUDENT WORKLOAD BY THE COURSE DESCRIPTION

Activities	Quantity	Duration (Hour)	Total Work Load (Hour)
Course Duration (14 weeks/theoric+practical)	14	3	42
Hours for off-the-classroom study (Pre-study, practice)	14	7	98
Assignments	1	5	5
Mid-terms	1	15	15
Final examination	1	35	35
Total Work Load ECTS Credit of the Course			195 7,5

COURSE DETAILS

Select Year

Course Details

Course Code	Course Title	L+P Hour	Course Code	Language Of Instruction	Course Semester
BIO 589	MONOOXYGENASES	3 + 0	1	Turkish	2017-2018 Spring

Course Coordinator	E-Mail	Phone Number	Course Location	Attendance
Prof. Dr. ALAATTİN ŞEN	sena@pau.edu.tr		FEN B0002	%70

Goals		Examine the role of moonoxgenases in normal metabolic pathways and xenobiotics metabolism in detail along with the current publications.
Content		Fundamental concepts on oxidases and oxygenases. Mechanism of action of monooxygenases. Special emphasis will be given on human enzymes including cytochrome P450- and cytochrome b5-dependent monooxygenases, flavin containing monooxygenases and nitric oxide synthase. Their importance in health and disease. Their structure, active sites, endogenous and exogenous substrates, structure-activity relationships, membrane topology, isomeric forms, molecular biology, gene structures and control mechanisms. Functions in human biochemistry including cholesterol, steroid hormone and vitamin synthesis and degradation, in drug metabolism and chemical carcinogenesis. The course includes lectures and discussions of recent journal articles.

Topics

Weeks	Topics
1	Introduction
2	Models and Mechanisms of Cytochrome P450 Action.
3	Computational Approaches to Cytochrome P450 Function.¶
4	Structures of Cytochrome P450 Enzymes.¶
5	Electron Transfer Partners of Cytochrome P450.¶
6	Activation of Molecular Oxygen by Cytochrome P450.¶
7	Substrate Oxidation by Cytochrome P450 Enzymes.¶
8	Inhibition of Cytochrome P450 Enzymes.¶
9	Induction of Cytochrome P450 Enzymes.
10	Hormonal Regulation of Liver Cytochrome P450 Enzymes.¶
11	P450 Enzymes.¶
12	Cytochrome P450 and the Metabolism and Bioactivation of Arachidonic Acid and Eicosanoids.¶
13	Cytochrome P450s in Plants.¶
14	The Diversity and Importance of Microbial Cytochromes P450.

Materials

Materials are not specified.

Resources

Course Assessment

Assesment Methods	Percentage (%)	Assesment Methods Title
Final Exam	50	Final Exam
Midterm Exam	50	Midterm Exam

L+P: Lecture and Practice
PQ: Program Learning Outcomes
LO: Course Learning Outcomes

Prospective Student