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COURSE INFORMATION
Course CodeCourse TitleL+P HourSemesterECTS
BIO 542SIGNAL TRANSDUCTION AND METABOLIC PATHWAYS3 + 02nd Semester7,5

COURSE DESCRIPTION
Course Level Master's Degree
Course Type Elective
Course Objective This course is designed to provide students with up-to-date account of the biochemical basis of the signal transduction mechanisms and metabolic pathways. The emphasis is general principles of cell signaling, the significance of cell signal transduction in health and disease and detailed information of techniques frequently used for the studies of cell signal.
Course Content The Regulation of Gene Expression, The Regulation of Enzyme Activity, Function and Structure of SignalingPathways, Signaling by Nuclear Receptors, G-protein Coupled Signal Transmission Pathways, Intracellular Messenger Substances: “Second Messengers”, Ser/Thr-specific ProteinKinases and ProteinPhosphatases, Signal Transmission via Transmembrane Receptors with Tyrosine-specific Protein Kinase Activity, SignalTransmission via Ras Proteins, Intracellular Signal Transduction: the Protein Cascades of the MAP Kinase Pathways , Receptor Classes, Ion Channels and Signal Transduction.
Prerequisites No the prerequisite of lesson.
Corequisite No the corequisite of lesson.
Mode of Delivery Face to Face

COURSE LEARNING OUTCOMES
1Will be able to know Function and Structure of Signaling Pathways
2Will be able to know Signaling by Nuclear Receptors
3Will be able to know G-protein Coupled Signal Transmission Pathways
4Will be able to know Intracellular Messenger Substances
5Will be able to know Kinase Pathways
6Will be able to know Receptor Classes
7Will be able to know Ion Channels and Signal Transduction

COURSE'S CONTRIBUTION TO PROGRAM
PO 01PO 02PO 03PO 04PO 05PO 06PO 07PO 08PO 09PO 10PO 11
LO 00144 5 5  45 
LO 002 54544     
LO 003 554       
LO 004  55       
LO 005445        
LO 006 454 54    
LO 007  5  444   
Sub Total82229234188445 
Contribution13431311110

ECTS ALLOCATED BASED ON STUDENT WORKLOAD BY THE COURSE DESCRIPTION
ActivitiesQuantityDuration (Hour)Total Work Load (Hour)
Course Duration (14 weeks/theoric+practical)14342
Hours for off-the-classroom study (Pre-study, practice)14798
Assignments155
Mid-terms11515
Final examination13535
Total Work Load

ECTS Credit of the Course






195

7,5
COURSE DETAILS
 Select Year   


 Course TermNoInstructors
Details 2016-2017 Fall1ALAATTİN ŞEN
Details 2015-2016 Spring1ALAATTİN ŞEN
Details 2013-2014 Fall1ALAATTİN ŞEN


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Course Details
Course Code Course Title L+P Hour Course Code Language Of Instruction Course Semester
BIO 542 SIGNAL TRANSDUCTION AND METABOLIC PATHWAYS 3 + 0 1 Turkish 2016-2017 Fall
Course Coordinator  E-Mail  Phone Number  Course Location Attendance
Prof. Dr. ALAATTİN ŞEN sena@pau.edu.tr FEN B0213 %85
Goals This course is designed to provide students with up-to-date account of the biochemical basis of the signal transduction mechanisms and metabolic pathways. The emphasis is general principles of cell signaling, the significance of cell signal transduction in health and disease and detailed information of techniques frequently used for the studies of cell signal.
Content The Regulation of Gene Expression, The Regulation of Enzyme Activity, Function and Structure of SignalingPathways, Signaling by Nuclear Receptors, G-protein Coupled Signal Transmission Pathways, Intracellular Messenger Substances: “Second Messengers”, Ser/Thr-specific ProteinKinases and ProteinPhosphatases, Signal Transmission via Transmembrane Receptors with Tyrosine-specific Protein Kinase Activity, SignalTransmission via Ras Proteins, Intracellular Signal Transduction: the Protein Cascades of the MAP Kinase Pathways , Receptor Classes, Ion Channels and Signal Transduction.
Topics
WeeksTopics
1 General Features of Signal Transduction
2 G Protein–Coupled Receptors and Second Messengers
3 Receptor Tyrosine Kinases
4 Receptor Guanylyl Cyclases, cGMP, and Protein Kinase G
5 Multivalent Scaffold Proteins and Membrane Rafts
6 Gated Ion Channels
7 Integrins: Bidirectional Cell Adhesion Receptors
8 Regulation by Steroid Hormones
9 Control of Carbohydrate Metabolism
10 Control of Lipid Metabolism
11 Control of nitrogen Metabolism
12 Sensory Transduction in Vision, Olfaction, and Gustation
13 Regulation of the Cell Cycle by Protein Kinases
14 Oncogenes, Tumor Suppressor Genes, and Programmed Cell Death
Materials
Materials are not specified.
Resources
Course Assessment
Assesment MethodsPercentage (%)Assesment Methods Title
Final Exam50Final Exam
Midterm Exam50Midterm Exam
L+P: Lecture and Practice
PQ: Program Learning Outcomes
LO: Course Learning Outcomes